t-Boc-N-Amido-PEG3-CH2CO2-NHS Ester (CAS: 1073289-14-1)
t-Boc-N-Amido-PEG3-CH2CO2-NHS Ester acts as a bifunctional PEG linker designed for bioconjugation and drug development. Its NHS ester efficiently reacts with primary amines, forming stable amide bonds. Meanwhile, its t-butoxycarbonyl (Boc)-protected amine undergoes deprotection under acidic conditions, revealing a free amine group. Additionally, the PEG3 spacer enhances water solubility and molecular flexibility, reducing steric hindrance during conjugation.
Key Features:
- Functional Groups:
- NHS Ester: Couples with primary amines, forming durable amide bonds.
- Boc-Protected Amine: Deprotects under acidic conditions, releasing a reactive amine group for additional modifications.
- PEG Spacer:
- Boosts solubility and flexibility, making molecular conjugation easier while minimizing steric interference.
Applications:
- Bioconjugation:
- Links biomolecules such as proteins, peptides, and small molecules, supporting complex molecular designs.
- Drug Development:
- Functions as a linker in synthesizing antibody-drug conjugates (ADCs) and other targeted therapies, improving drug delivery and stability.
Handling and Storage:
- Molecular Formula: C₁₇H₂₈N₂O₉
- Molecular Weight: 388.42 g/mol
- Purity: ≥95%
- Storage: Store in a cool, dry place, away from light and moisture to maintain product integrity.
In summary, t-Boc-N-amido-PEG3-NHS ester accelerates research by enabling precise and efficient bioconjugation processes. Its dual reactivity and flexible PEG3 spacer make it essential for applications in chemical biology, pharmaceutical development, and advanced drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
