t-Boc-N-Amido-PEG1-CH₂CO₂-NHS Ester, t-Boc-N-Amido-PEG1 NHS acetate (CAS 2742886-94-6)
This compound is a heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected amine and an NHS ester, separated by a single PEG unit and a methylene carboxylate spacer. The NHS ester reacts efficiently with primary amines, facilitating the conjugation of the PEG linker to various biomolecules. The PEG spacer enhances solubility in aqueous media, making it valuable in bioconjugation and drug development applications.
Chemical Properties:
- Chemical Formula: C₁₆H₂₄N₂O₈
- Molecular Weight: 372.37 g/mol
- Physical State: Typically a white to off-white solid
- Purity: ≥95%
Applications:
- Bioconjugation: Facilitates the attachment of PEG chains to proteins, peptides, or other amine-containing molecules, enhancing their solubility and stability.
- Drug Development: Serves as a linker in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
- Surface Modification: Useful in modifying surfaces to improve biocompatibility and reduce nonspecific binding in biomedical devices.
Storage and Handling:
- Storage Conditions: Store at -20°C in a dry environment to maintain stability.
- Safety Measures: Handle with appropriate protective equipment; consult the Safety Data Sheet (SDS) for detailed information.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
