t-Boc-Aminooxy-PEG8-alcohol linker contains a Boc-protected aminooxy group and an alcohol group. The PEG spacer increases the aqueous solubility of the resulting compound. The aminooxy has been used to conjugate with carbonyl bearing (ketone and aldehyde) biomolecules to form oxime for reversible linkage spacer.Oxime ligation is one of the hot topics in the field of bioconjugation of molecules due to its chemoselectivity and hydrolytic stability. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.