t-Boc-Aminooxy-PEG4-t-butyl ester CAS:1872433-64-1 is a versatile, bifunctional linker with a t-Boc protected aminooxy group and a t-butyl ester group. The t-Boc protection allows for orthogonal deprotection and coupling to carbonyl groups, while the t-butyl ester offers selective hydrolysis to release carboxylic acids. The PEG4 spacer enhances solubility, reduces aggregation, and increases bioavailability.
Introduction to the application:
In pharmaceutical research and development, t-Boc-Aminooxy-PEG4-t-butyl ester serves as a critical tool for creating bioconjugates and prodrugs. Its unique bifunctionality enables site-specific conjugation of drugs to targeted biomolecules, such as antibodies or peptides, improving therapeutic efficacy and reducing side effects. Additionally, its hydrolyzable t-butyl ester group can be utilized in prodrug design, releasing active molecules upon enzymatic cleavage in the body.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.