t-Boc-Aminooxy-PEG2-CH2CO2tBu CAS:2100306-57-6 is a bifunctional reagent that combines the protective groups of tert-butoxycarbonyl (t-Boc) and tert-butyl (tBu) with a polyethylene glycol (PEG) spacer. This reagent offers unique advantages in pharmaceutical research and development by enabling efficient conjugation of molecules and facilitating the controlled release of active compounds.
The t-Boc group shields the aminooxy functionality during synthesis, preventing unwanted side reactions. Once the desired modifications are made, the t-Boc group can be removed under mild acidic conditions, exposing the reactive aminooxy moiety for selective oxime or hydrazone bond formation.
The PEG2 spacer enhances the solubility and biocompatibility of conjugated molecules, reducing potential toxicity and immunogenicity. Additionally, the tBu-protected carboxylic acid can be selectively deprotected to reveal a versatile carboxyl group, allowing for the attachment of various bioactive molecules, drug payloads, or targeting ligands.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.