Sulfo DBCO-PEG3-NHS ester contains a sulfo-DBCO functional group, which is a clickable group that reacts selectively with azide-functionalized molecules through a highly specific and bioorthogonal click reaction. Sulfo DBCO-PEG3-NHS ester is widely used in the field of pharmaceutical research and development for its ability to enable site-specific conjugation of therapeutic molecules, such as antibodies, peptides, and small molecules, to biomolecules of interest.
The reactive NHS ester group in Sulfo DBCO-PEG3-NHS ester allows for the covalent attachment of the compound to amino groups on the target molecule, creating a stable amide bond. The PEG3 spacer group in the molecule imparts increased water solubility and biocompatibility, while the sulfo-DBCO group enables specific conjugation to azide-functionalized molecules.
Sulfo DBCO-PEG3-NHS ester has been utilized in the development of various drug delivery systems, such as antibody-drug conjugates (ADCs), which are highly targeted and effective therapeutic agents for the treatment of cancer and other diseases. The bioorthogonal nature of the click reaction allows for selective conjugation of the therapeutic agent to the target biomolecule, minimizing off-target effects and improving efficacy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
