(S,R,S)-AHPC-PEG4-amine hydrochloride salt
This product is a high-purity heterobifunctional linker featuring an AHPC (hydroxyproline-based ligand) for binding to VHL E3 ligase and a terminal amine for conjugation. The PEG4 spacer enhances water solubility, flexibility, and reduces steric hindrance, making it suitable for PROTAC synthesis and other targeted protein degradation strategies.
Key Features and Benefits
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AHPC Ligand: High-affinity VHL E3 ligase binder for PROTAC design.
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PEG4 Spacer: Improves solubility, flexibility, and bioavailability.
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Terminal Amine: Versatile handle for conjugation with electrophiles.
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Hydrochloride Salt: Enhances stability and handling.
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High Purity: Suitable for sensitive medicinal chemistry applications.
Applications
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PROTAC drug discovery and optimization.
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Targeted protein degradation studies.
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Chemical biology and proteomics research.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use in anhydrous conditions; avoid prolonged exposure to moisture and light.
(S,R,S)-AHPC-PEG4-amine hydrochloride salt is a high-purity PEG4-linked AHPC VHL ligand with terminal amine, ideal for PROTAC synthesis and targeted degradation research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
