(S,R,S)-AHPC-PEG2-acid
This product is a small-molecule ligand featuring the AHPC moiety linked to a PEG2 spacer and a terminal carboxylic acid. It provides a versatile handle for amide coupling and is especially used in targeted protein degradation and PROTAC research.
Key Features and Benefits
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AHPC Moiety: Recognized ligand for VHL E3 ligase in PROTAC applications.
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PEG2 Spacer: Provides solubility and flexibility while maintaining compact size.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PROTAC Utility: Serves as a building block for targeted protein degradation systems.
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High Purity: Supports reproducibility in sensitive medicinal chemistry workflows.
Applications
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Targeted Protein Degradation: Core ligand for constructing VHL-based PROTACs.
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Medicinal Chemistry: Intermediate for small-molecule drug discovery.
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Probe Development: Builds bifunctional probes for studying protein–ligand interactions.
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Bioconjugation: Couples to amines in linkers, peptides, or scaffolds.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to avoid hydrolysis.
This product integrates the VHL-binding AHPC ligand with a PEG2 spacer and carboxyl chemistry, specifically making it a key intermediate for PROTAC and protein degradation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
