SGD-1882(PBD-dimer) CAS:1222490-34-7 is a cutting-edge, cytotoxic, DNA minor-groove crosslinking agent belonging to the family of pyrrolobenzodiazepine (PBD) dimers.As a PBD dimer, SGD-1882 functions through a unique mechanism of action that involves crosslinking DNA within the minor groove. This interaction results in the inhibition of DNA replication and transcription, ultimately leading to cell cycle arrest and apoptosis. Due to its highly specific and potent cytotoxic properties, SGD-1882 has emerged as a promising payload for Antibody-Drug Conjugates (ADCs), offering a targeted and highly effective means of treating malignant tumors.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.