S-Acetyl-PEG3-azide
This product is a heterobifunctional linker featuring an S-acetyl-protected thiol and a terminal azide for click chemistry. The PEG3 spacer enhances solubility, flexibility, and spacing, making it especially useful for bioorthogonal conjugation, probe development, and redox-sensitive bioconjugation.
Key Features and Benefits:
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S-Acetyl Group: Provides a protected thiol that can be deprotected when required.
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkynes.
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PEG3 Spacer: Improves solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Supports orthogonal, controlled conjugation strategies.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Couples biomolecules via thiol and click chemistry handles.
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Probe Development: Builds multifunctional probes with controlled reactivity.
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Drug Delivery: Supports redox-sensitive linker strategies for targeted release.
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Synthetic Chemistry: Useful intermediate for orthogonal scaffold construction.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature deprotection.
This product integrates a protected thiol with a bioorthogonal azide group, offering especially versatile functionality for conjugation, controlled release, and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.