S-Acetyl-PEG-azide contains an azide functional group (-N3) attached to the terminal carbon atom of a PEG chain, which is acetylated to protect the amine functional group (-NH2) of the PEG.
The azide group is known for its ability to undergo a variety of chemical reactions, such as the Huisgen cycloaddition, also known as click chemistry. Click chemistry is a powerful tool in pharmaceutical research and development, allowing for the efficient and selective conjugation of two molecules through a covalent bond formation. S-Acetyl-PEG-azide has been extensively used as a click chemistry reagent for the bioconjugation of biomolecules, such as proteins, peptides, and nucleic acids, to PEGylated surfaces or other drugs.
S-Acetyl-PEG-azide has also been employed in the development of novel drug delivery systems, such as micelles, liposomes, and nanoparticles. Its unique chemical properties allow for the covalent attachment of therapeutic agents to the PEG chain via click chemistry reactions. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.