Propargyl-PEG6-acid
This bifunctional PEG6 linker carries a terminal alkyne and a carboxylic acid. The alkyne enables click chemistry with azides, while the acid couples with amines, making it a versatile tool for bioconjugation and material science.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples with amines for stable amide bond formation.
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PEG6 Spacer: Enhances solubility, flexibility, and reduces steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Dual Reactivity: Supports orthogonal and stepwise conjugation strategies.
Applications:
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Click Chemistry: Propargyl–azide conjugation for efficient bioorthogonal labeling.
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Bioconjugation: Crosslink biomolecules through acid–amine and click reactions.
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Drug Delivery: Serves as a flexible spacer-linker for targeted therapeutics.
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Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) for optimal stability and reactivity.
This product combines alkyne click chemistry with carboxyl reactivity, providing an especially versatile tool for orthogonal conjugation in biomolecular and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
