Propargyl-PEG5-amine
This product is a heterobifunctional linker containing a terminal propargyl (alkyne) group, a PEG5 spacer, and a primary amine. The alkyne enables copper-catalyzed (CuAAC) or copper-free click chemistry with azides, while the amine couples efficiently with carboxyls or activated esters. The PEG5 chain specifically provides solubility, flexibility, and moderate spacing, making this reagent highly useful for dual-reactive conjugation.
Key Features and Benefits
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Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
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Primary Amine: Couples readily with carboxyls or NHS esters to form amide bonds.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines orthogonal click chemistry and amine coupling.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links azide- and carboxyl-functionalized biomolecules.
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Protein and Antibody Labeling: Provides orthogonal handles for selective modifications.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Serves as a PEGylated linker for targeted therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines alkyne click reactivity with amine functionality on a PEG5 backbone, specifically offering versatility for chemical biology, probe design, and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
