Propargyl-PEG5-acid
This product is a heterobifunctional PEG5 linker featuring a terminal propargyl (alkyne) group for click chemistry and a carboxylic acid for amide coupling. The PEG5 spacer provides hydrophilicity, flexibility, and reduced steric hindrance, making it an especially versatile reagent for bioconjugation, drug delivery, and advanced material science.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC and SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples efficiently with primary amines to form stable amide bonds.
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PEG5 Spacer: Provides solubility, flexibility, and compact chain length.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Supports orthogonal and multistep conjugation strategies.
Applications:
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Click Chemistry: Copper-catalyzed or copper-free azide–alkyne cycloaddition.
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Bioconjugation: Links proteins, peptides, or biomolecules via orthogonal handles.
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Drug Delivery: PEGylated linker improves solubility, pharmacokinetics, and stability.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain alkyne and acid stability.
This product offers click-ready alkyne and reactive carboxyl groups in a hydrophilic PEG spacer, making it especially ideal for multifunctional bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
