Propargyl-PEG4-azide
Propargyl-PEG4-azide is a high-purity, heterobifunctional PEG linker with a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry and an azide for copper-free strain-promoted alkyne–azide cycloaddition (SPAAC) or additional CuAAC reactions. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance, enabling especially efficient and orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Propargyl Group – Supports CuAAC click chemistry for stable triazole formation.
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Azide Group – Compatible with CuAAC and SPAAC for bioorthogonal conjugation.
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PEG4 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible performance.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and small molecule modification
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Multifunctional probe and diagnostic agent synthesis
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Nanoparticle and surface functionalization
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Drug delivery systems and ADC linker design
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity
This product combines terminal alkyne and azide functionalities in one linker, separated by a PEG4 spacer for solubility and flexibility, specifically enabling efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
