Propargyl-PEG4-acid
Propargyl-PEG4-acid is a high-purity PEG linker with a terminal alkyne for copper-catalyzed or copper-free click chemistry and a carboxylic acid for orthogonal conjugation. The PEG4 spacer enhances solubility and flexibility, ensuring efficient bioconjugation in aqueous and organic systems for drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Terminal Alkyne: Enables copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted click chemistry.
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Carboxylic Acid Group: Couples efficiently to primary amines via carbodiimide chemistry (e.g., EDC/NHS).
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PEG4 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal and stepwise conjugation strategies.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Click Chemistry Bioconjugation: Attach alkynes to azide-bearing molecules.
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Protein and Peptide Modification: Combine click chemistry with acid–amine coupling.
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Nanoparticle and Surface Functionalization: Introduce bioorthogonal handles for targeted delivery systems.
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Drug Delivery Systems: Construct linkers for precise payload attachment and release.
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Diagnostic Probe Development: Build multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
This product combines alkyne click chemistry reactivity with a carboxylic acid handle in a hydrophilic PEG4 spacer, offering a soluble and flexible linker specifically for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
