Propargyl-PEG3-acid
This product is a bifunctional PEG3 linker with a terminal alkyne for click chemistry and a carboxylic acid for amide coupling. The short PEG3 spacer improves solubility and flexibility, making it an especially versatile reagent for bioconjugation, drug delivery, and material modification.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples efficiently with primary amines to form stable amide bonds.
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PEG3 Spacer: Provides hydrophilicity, flexibility, and reduced steric hindrance.
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High Purity: Suitable for sensitive and reproducible conjugation workflows.
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Dual Reactivity: Supports orthogonal and stepwise conjugation strategies.
Applications:
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Click Chemistry: Bioorthogonal conjugation with azide-bearing molecules.
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Bioconjugation: Attach proteins, peptides, or small molecules.
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Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve reactivity.
This product combines click-ready alkyne reactivity with carboxyl functionality in a short PEG spacer, making it especially useful for controlled bioconjugation and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
