Propargyl-PEG25-acid
This product is a long-chain bifunctional PEG25 linker with a terminal alkyne for click chemistry and a carboxylic acid for amide coupling. The extended PEG25 spacer provides excellent hydrophilicity, flexibility, and long-range spacing, making it especially valuable for bioconjugation, drug delivery, and surface functionalization.
Key Features and Benefits:
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Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples efficiently with primary amines to form amide bonds.
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PEG25 Spacer: Provides extended hydrophilicity, reduced steric hindrance, and improved spacing.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Enables orthogonal and stepwise conjugation strategies.
Applications:
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Click Chemistry: Alkyne–azide bioorthogonal labeling for proteins, peptides, and polymers.
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Bioconjugation: Dual-reactive linker for controlled biomolecule assembly.
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Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics of payloads.
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Surface Modification: Functionalizes nanoparticles, hydrogels, or biomaterials.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve alkyne and acid reactivity.
This product combines click-ready alkyne chemistry with carboxyl reactivity in a long PEG spacer, specifically offering flexibility for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
