Propargyl-PEG2-NHS ester
This product is a high-purity heterobifunctional PEG linker with a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry and an NHS ester for efficient coupling to primary amines. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, enabling especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Propargyl Group – Supports CuAAC click chemistry with azides for stable triazole linkage formation.
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NHS Ester – Reacts efficiently with primary amines on proteins, peptides, and other biomolecules.
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PEG2 Spacer – Enhances solubility and accessibility of reactive groups while minimizing steric hindrance.
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Orthogonal Reactivity – Allows sequential modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible results.
Applications
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Protein, peptide, and small molecule modification
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Antibody–drug conjugate (ADC) linker chemistry
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Multifunctional probe and diagnostic agent synthesis
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Nanoparticle and surface functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to preserve NHS ester reactivity
This product combines alkyne click chemistry with efficient amine coupling, connected by a PEG2 spacer for solubility and flexibility, specifically enabling precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
