Propargyl-PEG2-acid
This product is a bifunctional PEG2 linker with a terminal propargyl (alkyne) and a carboxylic acid. The alkyne supports click chemistry with azides, while the acid enables amide bond formation, making it a compact and versatile reagent for bioconjugation and material science.
Key Features and Benefits:
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Propargyl Group: Reactive handle for CuAAC or SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples with primary amines to form stable amide linkages.
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PEG2 Spacer: Improves solubility and flexibility while minimizing steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Enables orthogonal or stepwise conjugation strategies.
Applications:
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Click Chemistry: Bioorthogonal conjugation with azide-containing molecules.
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Bioconjugation: Attach proteins, peptides, and small molecules.
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Drug Delivery: Compact PEG linker to improve solubility and pharmacokinetics.
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Surface Functionalization: Modify nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain alkyne and acid reactivity.
This product combines alkyne click chemistry with carboxyl coupling in a short PEG spacer, specifically offering a compact tool for multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
