Propargyl-PEG13-acid
This product is a heterobifunctional PEG13 linker with a terminal propargyl (alkyne) group for click chemistry and a carboxylic acid for amide coupling. The PEG13 spacer provides excellent hydrophilicity, flexibility, and medium-to-long spacing, making it especially suitable for bioconjugation, drug delivery, and advanced material applications.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC and SPAAC click chemistry with azides.
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Carboxylic Acid Group: Couples efficiently with primary amines to form stable amide bonds.
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PEG13 Spacer: Offers long hydrophilic spacing, solubility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive workflows.
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Dual Reactivity: Combines click-ready alkyne with classical amide bond formation.
Applications:
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Click Chemistry: Bioorthogonal azide–alkyne ligation for labeling and probe design.
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Bioconjugation: Dual-functional linker for proteins, peptides, and biomolecules.
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Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve alkyne and acid stability.
This product offers click-ready alkyne and carboxyl reactivity with extended PEG spacing, making it an especially versatile tool for advanced conjugation and drug delivery workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
