Propargyl-PEG12-amine
This product is a heterobifunctional PEG12 linker with a terminal propargyl (alkyne) group for click chemistry and a primary amine for amide coupling. The long PEG12 spacer provides excellent hydrophilicity, flexibility, and reduced steric hindrance, making it an especially versatile reagent for bioconjugation, drug delivery, and advanced material applications.
Key Features and Benefits:
-
Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
-
Amine Group: Couples efficiently with carboxyls, NHS esters, and electrophiles.
-
PEG12 Spacer: Offers long hydrophilic spacing and enhanced solubility.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
-
Dual Reactivity: Supports orthogonal and stepwise bioconjugation strategies.
Applications:
-
Click Chemistry: Bioorthogonal labeling through azide–alkyne ligation.
-
Bioconjugation: Dual-reactive linker for proteins, peptides, and biomolecules.
-
Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
-
Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve alkyne and amine reactivity.
This product provides click-ready alkyne and amine functionalities with extended PEG spacing, making it an especially powerful tool for advanced conjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
