Poly(L-Ornithine)-mPEG, MW x 10K, n 1K is a functional block copolymer composed of poly(L-ornithine) (PLO) and methoxy polyethylene glycol (mPEG). This grade combines approximately 10K PLO with 1K mPEG, providing a strongly PLO-rich architecture with abundant pendant primary amine groups and a hydrophilic PEG segment specifically for polymer functionalization, bioconjugation, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines amine-functional PLO with hydrophilic mPEG for polymer modification, conjugation, drug delivery, and biomaterial development.
- PLO MW 10K: Provides a substantial poly(amino acid) segment with abundant pendant primary amine groups for molecular interactions and chemical modification.
- mPEG MW 1K: Provides a hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- Strongly PLO-Rich Architecture: The 10:1 PLO-to-mPEG molecular weight ratio strongly favors amine-functional PLO content while retaining a hydrophilic mPEG component.
- Amine-Functional Polymer: The PLO block provides pendant primary amine groups for ionic interactions, chemical modification, and conjugation.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy PEG terminus while the PLO block supplies functional sites for further modification.
- Functionalizable Polymer Platform: Enables modification of PLO amine groups using amine-reactive chemistries for attachment of drugs, peptides, ligands, and other functional molecules.
Applications
- Polymer Functionalization: Provides pendant primary amine groups for chemical modification and attachment of functional molecules.
- Bioconjugation: Supports coupling with carboxyl-, NHS ester-, or other amine-reactive molecules for preparation of functional conjugates.
- Drug Delivery: Supports development of functional polymer systems, polymer-drug conjugates, and drug-delivery carriers.
- Ionic Complex Formation: Provides amine-containing PLO segments for electrostatic interactions with negatively charged molecules and materials.
- Surface Modification: Supports attachment of functional molecules and development of modified polymeric surfaces.
- Polymer Conjugates: Enables preparation of PEG-poly(amino acid) conjugates with drugs, peptides, targeting ligands, and other functional molecules.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for coatings, conjugates, hydrogels, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines amine-functional PLO with hydrophilic mPEG in a strongly PLO-rich architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
