Poly(L-Aspartic Acid)-PEG-N3 (pAsp-PEG-N3), MW x 3K, n 5K is an azide-functionalized block copolymer composed of poly(L-aspartic acid) (pAsp) and polyethylene glycol (PEG). This grade combines approximately 3K pAsp with 5K PEG and terminal azide (N3) functionality, specifically providing a PEG-rich architecture with multiple carboxyl groups and a reactive handle for click chemistry, bioconjugation, and biomaterial development.
Key Features and Benefits
- Functional Block Copolymer: Combines carboxyl-rich pAsp with hydrophilic PEG for drug delivery, bioconjugation, and biomaterial research.
- pAsp MW 3K: Provides a polyanionic poly(amino acid) segment with multiple carboxyl groups for molecular interactions and chemical modification.
- PEG MW 5K: Provides a substantial hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 3:5 pAsp-to-PEG molecular weight ratio especially favors hydrophilic character while retaining a functional carboxyl-rich pAsp segment.
- Azide Functionality: Provides a terminal N3 group for reaction with alkyne- or cyclooctyne-functionalized molecules through click chemistry.
- Carboxyl-Rich Polymer: The pAsp segment provides multiple pendant carboxyl groups that support further functionalization and interaction with suitable molecules or ions.
- Versatile Conjugation Platform: Combines terminal azide functionality with pendant carboxyl groups to support multiple routes for polymer modification and bioconjugation.
Applications
- Click Chemistry: Supports Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-functionalized molecules.
- Copper-Free Click Chemistry: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible cyclooctyne-functionalized molecules such as DBCO derivatives.
- Bioconjugation: Enables attachment of peptides, proteins, targeting ligands, probes, and other suitably functionalized molecules.
- Drug Delivery: Supports development of functional polymer-based drug delivery and carrier systems.
- Surface Functionalization: Provides azide and carboxyl functionality for modification of nanoparticles, biomaterials, and other polymeric systems.
- Biomaterial Research: Supports development of functional hydrophilic polymers, conjugates, coatings, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines a carboxyl-rich pAsp segment, a substantial hydrophilic PEG block, and terminal azide functionality. It specifically supports click chemistry, bioconjugation, drug delivery, surface functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
