Poly(ε-Caprolactone)-PEG-Poly(ε-Caprolactone) (PCL-PEG-PCL), MW x 1K, n 4K is an amphiphilic triblock copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG). It also has hydrophobic PCL blocks positioned on both sides of the hydrophilic PEG segment. This grade combines approximately 1K PCL with 4K PEG, providing an especially PEG-rich architecture for polymer self-assembly, drug delivery, controlled release, hydrogel development, and biomaterial research.
Key Features and Benefits
- Amphiphilic Triblock Copolymer: Combines hydrophobic PCL end blocks with a hydrophilic PEG central block for polymer assembly, drug delivery, and biomaterial development.
- PCL MW 1K: Provides biodegradable hydrophobic segments for polymer association, structural support, and interactions with hydrophobic compounds.
- PEG MW 4K: Provides a substantial hydrophilic central segment specifically for aqueous compatibility, hydration, and steric stabilization.
- Strongly PEG-Rich Architecture: The 1:4 PCL-to-PEG molecular weight ratio strongly favors hydrophilic character while retaining hydrophobic PCL segments for polymer association and assembly.
- PCL-PEG-PCL Architecture: The symmetric triblock structure places hydrophobic PCL blocks on both sides of PEG, supporting intermolecular association and formation of organized polymeric structures.
- Biodegradable Polymer Platform: Combines biodegradable PCL with hydrophilic PEG in a versatile polymer platform for drug delivery and biomaterial research.
Applications
- Polymer Self-Assembly: Supports formation of organized amphiphilic structures through association of hydrophobic PCL blocks in aqueous environments.
- Nanoparticle Formulation: Supports preparation of polymeric nanoparticles and other nanoscale delivery systems.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Hydrogel Development: Supports development of physically associated and crosslinked polymer networks for hydrogel research.
- Controlled Release: Provides a biodegradable polymer matrix for sustained and controlled-release applications.
- Biomaterial Development: Supports development of biodegradable polymer systems, scaffolds, coatings, and other functional biomaterials.
- Tissue Engineering Research: Supports investigation of PCL-PEG-PCL materials for scaffolds, matrices, and other tissue-engineering applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines shorter hydrophobic PCL blocks with a substantial hydrophilic PEG segment in a strongly PEG-rich amphiphilic triblock architecture. It specifically supports polymer self-assembly, nanoparticle formulation, drug delivery, controlled release, hydrogel development, tissue engineering, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.