PLLA-PEG-Azide (PLLA-PEG-N3), MW x 1K, n 5K is an azide-functionalized biodegradable block copolymer and specifically combines a 1K PLLA segment, 5K PEG segment, and terminal azide (–N₃) for click chemistry and biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: PLLA-PEG-Azide combines hydrophobic poly(L-lactide) with hydrophilic polyethylene glycol.
- PLLA MW 1K: The 1K PLLA segment provides a compact biodegradable and hydrophobic polyester component.
- PEG MW 5K: The 5K PEG segment specifically provides a substantial hydrophilic component and flexible polymer spacer.
- Azide Functionality: The terminal –N₃ group specifically provides a bioorthogonal reactive site for click chemistry and polymer modification.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide reacts with strained cyclooctynes such as DBCO without requiring a copper catalyst.
- Stable Triazole Formation: Azide-alkyne click reactions produce stable triazole linkages specifically for covalent conjugation.
- Amphiphilic Character: Hydrophobic PLLA and hydrophilic PEG support self-assembly in compatible formulation systems.
Applications
- Click Chemistry: PLLA-PEG-Azide (PLLA-PEG-N3) provides terminal azide functionality for CuAAC and SPAAC reactions.
- Bioconjugation: Supports attachment of compatible peptides, proteins, probes, and other functional molecules.
- Ligand Conjugation: Enables attachment of alkyne- or cyclooctyne-functionalized ligands through click chemistry.
- Nanoparticle Research: The amphiphilic block structure supports development of functional polymeric nanoparticles.
- Polymeric Micelles: Hydrophobic PLLA and hydrophilic PEG support self-assembly into compatible polymeric systems.
- Drug Delivery Research: Supports development of experimental functionalized polymer-based delivery systems.
- Surface Modification: Terminal azide functionality enables click-based modification of compatible surfaces and materials.
- Biomaterial Research: Supports development of biodegradable polymers, conjugates, nanoparticles, and functional biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Azide (PLLA-PEG-N3), MW x 1K, n 5K combines biodegradable PLLA, hydrophilic PEG, and click-reactive azide functionality and specifically supports CuAAC, SPAAC, bioconjugation, nanoparticle formulation, polymer modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.