PLGA Acid Capped (PLGA-COOH, 85:15), MW 5K

PLGA Acid Capped (PLGA-COOH, 85:15), MW 5K is a low-molecular-weight, carboxyl-terminated poly(D,L-lactide-co-glycolide) copolymer. Its lactide-rich 85:15 composition and reactive COOH end group specifically support controlled drug delivery, bioconjugation, and functional polymer development.

Key Features and Benefits

• Acid Capped: Provides a terminal carboxylic acid group for conjugation and further functionalization.
• 85:15 PLGA Ratio: High lactide content supports slower water uptake and controlled degradation.
• MW 5K: Offers low molecular weight for efficient processing and flexible formulation development.
• Reactive COOH Group: Supports coupling with amines after activation using standard carbodiimide chemistry.
• Controlled Degradation: Lactide-rich composition supports controlled hydrolytic degradation and drug-release profiles.
• Biodegradable: PLGA hydrolyzes into lactic acid and glycolic acid under physiological conditions.

Applications

• Controlled Drug Delivery: Supports drug release through biodegradable polymer matrices.
• Bioconjugation: Enables attachment of peptides, proteins, targeting ligands, and other amine-containing molecules.
• Nanoparticles: Forms functional PLGA nanoparticles for drug delivery and formulation research.
• Microparticles: Supports biodegradable microspheres and other controlled-release particle systems.
• Polymer Modification: Provides a reactive COOH group for introducing linkers, ligands, and functional molecules.

Storage and Handling

• Storage: Store at –20 °C in a fully sealed container under dry and dark conditions.
• Handling: Protect from moisture, light, and excessive heat to maintain molecular weight and polymer performance.

PLGA Acid Capped (PLGA-COOH, 85:15), MW 5K combines low-molecular-weight PLGA with reactive carboxyl functionality. Its lactide-rich composition specifically supports controlled drug delivery, bioconjugation, particle formulation, and functional biodegradable polymer development.