PEG3-Tos
This product is a tosyl-activated polyethylene glycol derivative with a three-unit PEG chain terminated by a tosyl (p-toluenesulfonyl) group. The short PEG3 spacer provides moderate solubility and flexibility, while the tosyl group acts as a highly reactive leaving group for nucleophilic substitution, making it a versatile intermediate for preparing functionalized PEG derivatives.
Key Features and Benefits
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Tosyl Group (Tos): Serves as an excellent leaving group for substitution with amines, thiols, or alkoxides.
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PEG3 Spacer: Offers improved solubility and reduced steric hindrance in conjugation reactions.
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Compact Design: Provides a shorter linker compared to long-chain PEG-Tos derivatives, useful for precise modifications.
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Synthetic Versatility: Acts as a key intermediate for PEG-based reagents and crosslinkers.
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High Purity: Produced to ≥95% purity for consistent and reproducible synthesis.
Applications
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PEG Derivatization: Converts into PEG-amines, PEG-thiols, and PEG-alcohols via nucleophilic substitution.
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Bioconjugation: Serves as a precursor for PEG linkers in drug delivery and probe development.
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Surface Modification: Functionalizes nanoparticles and materials to enhance solubility and biocompatibility.
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Organic Synthesis: Provides a starting material for diverse PEG intermediates.
Storage and Handling
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Storage: Store at –20 °C in a dry, sealed container, away from light and moisture.
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Handling: Use under inert conditions when possible; dissolve freshly before reaction.
This product combines the high reactivity of a tosyl group with a short PEG3 chain, making it an especially valuable intermediate for nucleophilic substitution and PEGylation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
