PEG13-Tos
This product is a monofunctional PEG linker featuring a tosyl (p-toluenesulfonyl) reactive group and a PEG13 spacer. The tosyl group acts as an excellent leaving group, specifically enabling nucleophilic substitution to generate custom PEG derivatives for synthesis and bioconjugation.
Key Features and Benefits
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Tosyl Group: Effective leaving group for substitution with thiols, amines, or alkoxides.
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PEG13 Spacer: Provides extended hydrophilicity and solubility.
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Reactive Intermediate: Serves as a precursor for functional PEG linkers.
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Flexible Length: PEG13 offers enhanced spacing for sterically sensitive systems.
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High Purity: Ensures reproducibility in synthesis and bioconjugation workflows.
Applications
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Organic Synthesis: Prepares functional PEG derivatives through tosyl substitution.
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Bioconjugation: Builds PEGylated linkers for proteins, peptides, and small molecules.
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Material Science: Introduces PEG functionality into polymers and nanostructures.
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Drug Delivery: Constructs PEG scaffolds with improved solubility and stability.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates a tosyl leaving group with a long PEG13 spacer, specifically providing a soluble and reactive intermediate for linker synthesis, conjugation, and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
