PDLLA-PEG-Biotin, MW x 10K, n 3K is a functional amphiphilic block copolymer with terminal biotin. It combines a 10K hydrophobic PDLLA block with a 3K hydrophilic PEG block for affinity-based functionalization and drug-delivery research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for self-assembly, formulation, and biomaterial development.
- PDLLA MW 10K: Provides a biodegradable hydrophobic block specifically for core formation, structural support, and incorporation of hydrophobic compounds.
- PEG MW 3K: Provides a hydrophilic segment specifically for aqueous compatibility, steric stabilization, and surface presentation.
- Terminal Biotin: Provides a high-affinity recognition site for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin forms strong, specific noncovalent interactions with avidin and streptavidin.
- PDLLA-Rich Architecture: The approximately 3.3:1 PDLLA-to-PEG molecular weight ratio specifically favors hydrophobic character while retaining a substantial PEG segment.
- Biodegradable PDLLA Block: The PDLLA segment contains hydrolyzable ester linkages that support gradual degradation under appropriate conditions.
- Functional Polymer Platform: Terminal biotin enables affinity-based modification of micelles, nanoparticles, and related polymer systems.
Applications
- Polymeric Micelles: Supports self-assembled systems with a hydrophobic PDLLA region and hydrophilic PEG interface.
- Nanoparticle Formulation: Supports preparation of PEG-containing polymeric nanoparticles and related delivery systems.
- Avidin-Biotin Binding: Enables high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Affinity-Based Functionalization: Supports noncovalent attachment of compatible avidin- or streptavidin-containing components.
- Drug Delivery: Supports development of amphiphilic polymer systems specifically for drug-delivery and controlled-release research.
- Bioconjugation: Enables affinity-based association with biotin-binding proteins and compatible functional components.
- Surface Functionalization: Terminal biotin supports affinity-based modification of PEG-presenting polymer assemblies.
- Biomaterial Research: Supports development of functional micelles, nanoparticles, polymer conjugates, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-Biotin, MW x 10K, n 3K combines biodegradable PDLLA, hydrophilic PEG, and terminal biotin functionality and specifically supports self-assembly, affinity binding, nanoparticle functionalization, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.