PDLLA-PEG-Biotin, MW x 2K, n 1K is a biotin-functionalized amphiphilic block copolymer. It combines 2K hydrophobic PDLLA with 1K hydrophilic PEG specifically for self-assembly, affinity functionalization, and drug-delivery research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 2K: Provides a biodegradable hydrophobic block specifically for polymer assembly and incorporation of hydrophobic compounds.
- PEG MW 1K: Provides a short hydrophilic segment specifically for aqueous compatibility and surface presentation.
- Terminal Biotin: Provides a high-affinity recognition site for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin forms strong, specific noncovalent interactions with avidin and streptavidin.
- PDLLA-Rich Architecture: The 2:1 PDLLA-to-PEG molecular weight ratio especially favors hydrophobic character while retaining a hydrophilic PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages support gradual degradation of the PDLLA segment under appropriate conditions.
- Functional Polymer Platform: Terminal biotin supports affinity-based modification of nanoparticles, polymer assemblies, and related materials.
Applications
- Polymer Self-Assembly: Supports amphiphilic assemblies containing hydrophobic PDLLA and hydrophilic PEG domains.
- Nanoparticle Formulation: Supports preparation and functionalization of PEG-containing polymeric nanoparticles.
- Avidin-Biotin Binding: Enables high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Affinity-Based Functionalization: Supports noncovalent attachment of compatible avidin- or streptavidin-containing components.
- Drug Delivery: Supports development of amphiphilic polymer systems for drug-delivery and controlled-release research.
- Bioconjugation: Enables affinity-based association with biotin-binding proteins and compatible functional components.
- Surface Functionalization: Terminal biotin supports affinity-based modification of compatible polymer assemblies and surfaces.
- Biomaterial Research: Supports development of functional polymer conjugates, nanoparticles, assemblies, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-Biotin, MW x 2K, n 1K combines biodegradable PDLLA, a short PEG segment, and terminal biotin. Its PDLLA-rich architecture supports affinity binding, polymer assembly, nanoparticle functionalization, and drug-delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.