PCL-PEG-SH, MW x 1K, n 3K is a thiol-functionalized amphiphilic block copolymer. It combines a 1K poly(ε-caprolactone) (PCL) block with a 3K polyethylene glycol (PEG) block, and its PEG-rich architecture promotes aqueous compatibility and steric stabilization, while the terminal thiol enables conjugation and surface functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for polymer assembly and hydrophobic interactions.
- PEG MW 3K: Provides a dominant hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 3:1 PEG-to-PCL molecular weight ratio favors hydrophilic character and surface stabilization.
- Thiol Functionalization: Provides a terminal sulfhydryl group specifically for conjugation and surface modification.
- Versatile Reactivity: The thiol reacts with maleimides and other thiol-reactive functional groups under suitable conditions.
Applications
- Bioconjugation: Enables coupling with maleimide-functionalized peptides, proteins, ligands, and other molecules.
- Nanoparticle Functionalization: Supports functionalized nanoparticles, micelles, and PEG-rich polymer assemblies.
- Drug Delivery: Supports amphiphilic polymeric carriers and surface-functionalized drug delivery systems.
- Surface Functionalization: Terminal thiol supports attachment to compatible thiol-reactive surfaces and materials.
- Crosslinking Research: Supports preparation of functional polymer networks using thiol-reactive chemistry.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, heat, and oxidizing conditions. Thiol groups can oxidize to form disulfides.
PCL-PEG-SH, MW x 1K, n 3K combines a short PCL block with a longer PEG segment and terminal thiol functionality and specifically supports hydrophilic stabilization, bioconjugation, functionalized nanocarriers, and surface modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.