PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 4K, n 1K is a thiol-reactive amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a terminal maleimide group. The 4K PCL block provides a dominant hydrophobic domain for self-assembly and cargo incorporation, while the 1K PEG block provides surface functionality and presents maleimide for selective conjugation with thiol-containing molecules.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, functionalization, and drug delivery.
- PCL MW 4K: Provides a biodegradable hydrophobic segment specifically for core formation and hydrophobic cargo incorporation.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface functionality.
- PCL-Rich Architecture: The 4:1 PCL-to-PEG molecular weight ratio strongly favors hydrophobic interactions and core-forming assemblies.
- Maleimide Functionalization: Provides a terminal maleimide group for selective reaction with free sulfhydryl groups.
- Thiol Conjugation: Maleimide reacts with thiol-containing molecules to form stable covalent thioether linkages under suitable conditions.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, antibodies, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and other polymer assemblies.
- Drug Delivery: Supports hydrophobic cargo incorporation and functionalized polymeric carrier development.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands to PEG-presenting polymeric carriers.
- Surface Functionalization: Supports preparation of maleimide-presenting biomaterials and polymer surfaces for thiol coupling.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to aqueous or strongly basic conditions that may hydrolyze maleimide functionality.
This product combines a strongly PCL-rich architecture with thiol-reactive maleimide functionality and specifically supports hydrophobic drug incorporation, biomolecule conjugation, nanoparticle surface modification, and targeted drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.