PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 10K, n 5K is an amphiphilic block copolymer with a terminal maleimide group. This grade combines approximately 10K PCL with 5K PEG and the PCL-rich architecture supports hydrophobic assembly, while maleimide enables thiol-selective conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 10K: Provides a substantial biodegradable hydrophobic block specifically for core formation and hydrophobic drug incorporation.
- PEG MW 5K: Provides a hydrophilic segment for aqueous compatibility and steric stabilization.
- PCL-Rich Architecture: The 2:1 PCL-to-PEG ratio favors hydrophobic interactions and core-forming polymer assemblies.
- Maleimide Functionalization: Provides a terminal maleimide group for efficient thiol-selective conjugation.
- Thiol-Reactive: Maleimide reacts with sulfhydryl groups to form stable thioether linkages under suitable conditions.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, antibodies, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted delivery research.
- Ligand Attachment: Enables conjugation of thiolated targeting ligands and other sulfhydryl-containing molecules.
- Biomaterial Research: Supports development of functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat and avoid prolonged exposure to conditions that can degrade maleimide functionality.
This product combines a substantial PCL block with hydrophilic PEG and thiol-reactive maleimide that specifically supports targeted conjugation, polymer assembly, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.