PCL-PEG-Biotin, MW x 4K, n 5K is a biotin-functionalized amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG). This grade combines approximately 4K PCL with 5K PEG, providing a slightly PEG-rich architecture for aqueous stabilization and polymer assembly, while terminal biotin enables high-affinity interaction with avidin and streptavidin.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 4K: Provides a biodegradable hydrophobic segment for core formation and incorporation of hydrophobic compounds.
- PEG MW 5K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 5:4 PEG-to-PCL molecular weight ratio provides increased hydrophilic character and surface stabilization.
- Biotin Functionalization: Provides terminal biotin specifically for affinity-based binding and biomolecular recognition.
- Avidin/Streptavidin Binding: Enables strong noncovalent interaction with avidin, streptavidin, and related biotin-binding proteins.
Applications
- Nanoparticle Functionalization: Supports biotin-functionalized nanoparticles, micelles, and other polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted delivery research.
- Affinity Binding: Enables incorporation into biotin-avidin or biotin-streptavidin recognition systems.
- Bioconjugation: Supports indirect attachment of proteins, peptides, antibodies, and ligands through biotin-binding intermediates.
- Biomaterial Research: Supports development of functionalized biodegradable polymers and affinity-based biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid conditions that may compromise polymer integrity or biotin-binding performance.
PCL-PEG-Biotin, MW x 4K, n 5K combines biodegradable PCL with a slightly longer PEG block and terminal biotin functionality and specifically supports affinity-based bioconjugation, stabilized polymer assemblies, targeted drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.