PCL-mPEG, MW x 4K, n 5K is an amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and methoxy polyethylene glycol (mPEG). This grade combines approximately 4K PCL with 5K mPEG, providing a slightly mPEG-rich architecture for aqueous stabilization and polymer self-assembly while retaining a biodegradable PCL segment for hydrophobic interactions and drug incorporation.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic mPEG for polymer assembly and drug delivery.
- PCL MW 4K: Provides a biodegradable hydrophobic block for core formation and incorporation of hydrophobic compounds.
- mPEG MW 5K: Provides a substantial hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- mPEG-Rich Architecture: The 4:5 PCL-to-mPEG molecular weight ratio provides slightly greater hydrophilic character while maintaining a significant hydrophobic PCL block.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy end group specifically for PEG surface coverage without additional conjugation chemistry.
- Biodegradable Polymer Platform: Combines a degradable polyester block with hydrophilic PEG for drug delivery and biomaterial research.
Applications
- Nanoparticle Formulation: Supports preparation of polymeric nanoparticles and other nanoscale delivery systems.
- Micelle Formation: Supports core-shell assemblies with a hydrophobic PCL core and hydrophilic PEG corona.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Controlled Release: Supports biodegradable polymer systems designed for sustained or controlled release.
- Biomaterial Research: Supports development of PEGylated biodegradable materials and polymer-based delivery platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PCL-mPEG, MW x 4K, n 5K combines a slightly mPEG-rich architecture with a biodegradable hydrophobic PCL segment and specifically supports polymer self-assembly, nanoparticle formulation, micelle formation, hydrophobic drug delivery, controlled release, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.