PCL-mPEG, MW x 1K, n 2K is an amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and methoxy polyethylene glycol (mPEG). This grade combines approximately 1K PCL with 2K mPEG, providing an mPEG-rich architecture for aqueous stabilization and polymer self-assembly while retaining a biodegradable PCL segment for hydrophobic interactions and drug incorporation.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic mPEG for polymer assembly and drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic block for core formation and interaction with hydrophobic compounds.
- mPEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- mPEG-Rich Architecture: The 1:2 PCL-to-mPEG molecular weight ratio favors hydrophilic character and aqueous stabilization while retaining a hydrophobic PCL component.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy end group for PEG surface coverage without additional conjugation chemistry.
- Biodegradable Polymer Platform: Combines a degradable polyester block with hydrophilic PEG for drug delivery and biomaterial research.
Applications
- Nanoparticle Formulation: Supports preparation of PEG-rich polymeric nanoparticles and other nanoscale delivery systems.
- Micelle Formation: Supports core-shell assemblies with a hydrophobic PCL core and hydrophilic PEG corona.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Controlled Release: Supports biodegradable polymer systems designed for sustained or controlled release.
- Biomaterial Research: Supports development of PEGylated biodegradable materials and polymer-based delivery platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PCL-mPEG, MW x 1K, n 2K combines an mPEG-rich architecture with a short biodegradable PCL segment and specifically supports aqueous-compatible polymer assembly, nanoparticle formulation, micelle formation, drug delivery, controlled release, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.