PC DBCO-PEG3-Biotin
This product is a multifunctional PEG linker containing a photocleavable (PC) group, a dibenzocyclooctyne (DBCO) moiety, a PEG3 spacer, and a biotin tag. It specifically enables copper-free click chemistry with azides, high-affinity biotin–streptavidin binding, and light-triggered release for controlled conjugation.
Key Features and Benefits
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Photocleavable Group: Allows light-triggered release of conjugated molecules.
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DBCO Group: Performs copper-free strain-promoted azide–alkyne cycloaddition (SPAAC).
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Biotin Moiety: Provides strong binding affinity to streptavidin and avidin.
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PEG3 Spacer: Improves solubility and reduces steric hindrance.
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Dual Reactivity + Controlled Release: Combines bioorthogonal click chemistry, affinity binding, and photocleavage.
Applications
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Bioconjugation: Links azide-modified biomolecules with biotin-binding systems.
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Probe Development: Creates multifunctional probes with affinity, click, and photocleavage functions.
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Drug Delivery: Enables light-controlled release of targeted conjugates.
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Material Science: Functionalizes polymers and nanostructures with dual reactivity and photocleavage.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged light exposure.
This product integrates DBCO click chemistry, biotin–streptavidin binding, and photocleavable release in a PEG3 scaffold, offering an especially versatile linker for advanced probe design and controlled bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
