PC-Biotin-PEG4-PEG4-alkyne
This product is a multifunctional bioconjugation reagent that integrates a biotin tag, two PEG4 spacers, and a terminal alkyne group. The biotin enables high-affinity binding to streptavidin, while the alkyne allows copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The dual PEG4 linkers specifically provide flexibility, solubility, and reduced steric hindrance, ensuring efficient labeling and conjugation.
Key Features and Benefits
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Biotin Tag: Binds strongly to streptavidin, avidin, and NeutrAvidin systems for capture and detection.
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Dual PEG4 Spacers: Enhance solubility, reduce steric interference, and provide flexible spacing between functional groups.
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Terminal Alkyne Group: Supports CuAAC click chemistry with azides for efficient and selective conjugation.
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Multifunctional Design: Combines biotin affinity with alkyne reactivity for orthogonal conjugation strategies.
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High Purity: Manufactured to ≥95% purity for reliable and reproducible results.
Applications
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Bioconjugation: Couples biotin to azide-containing biomolecules, drugs, or probes.
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Affinity Capture: Labels and immobilizes biomolecules on streptavidin-coated beads, plates, or sensors.
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Probe Development: Builds multifunctional probes for imaging, diagnostics, and chemical biology.
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Drug Delivery Research: Supports targeted delivery through dual functional handles.
Storage and Handling
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Storage: Store at –20 °C in a tightly sealed container, protected from light and moisture.
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Handling: Dissolve freshly in dry DMSO or DMF; avoid repeated freeze–thaw cycles.
This product combines strong biotin–streptavidin affinity with versatile alkyne click chemistry, specifically offering a powerful tool for advanced bioconjugation, probe development, and affinity-based research applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
