PC-Biotin-PEG3-azide
This product is a multifunctional linker containing a photocleavable (PC) group, a biotin tag, a PEG3 spacer, and a terminal azide. The photocleavable group allows controlled release upon light activation, while the azide enables copper-catalyzed or copper-free click chemistry with alkynes. The biotin specifically provides high-affinity binding to streptavidin and avidin systems, and the PEG3 spacer enhances solubility and reduces steric hindrance.
Key Features and Benefits
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Photocleavable Group: Enables light-triggered release of biotin or conjugated payloads.
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Biotin Tag: Strong binding to streptavidin, avidin, and NeutrAvidin.
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Azide Group: Supports CuAAC or SPAAC click chemistry with alkynes.
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PEG3 Spacer: Improves solubility, flexibility, and biomolecule accessibility.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Photo-Responsive Bioconjugation: Allows controlled release of biotinylated molecules with UV light.
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Affinity Capture and Release: Enables reversible immobilization on streptavidin-coated supports.
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Probe Development: Builds multifunctional probes for proteomics and imaging.
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Chemical Biology: Supports orthogonal labeling and light-triggered control strategies.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Protect from light; prepare fresh solutions before use.
This product combines light-cleavable control, click reactivity, and strong biotin affinity in a compact PEG3 scaffold, making it an especially powerful reagent for reversible bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
