pAsp-PEG-pAsp, MW x 2.3K, n 2K is a triblock copolymer composed of poly(L-aspartic acid) (pAsp) and polyethylene glycol (PEG), with pAsp blocks positioned on both sides of the central PEG segment. This grade combines approximately 2.3K pAsp with 2K PEG, providing a near-balanced architecture with multiple carboxyl groups specifically for chemical modification, molecular interactions, drug delivery, and biomaterial development.
Key Features and Benefits
- Triblock Copolymer Architecture: Combines two pAsp segments with a central PEG block to provide a functional pAsp-PEG-pAsp polymer platform.
- pAsp MW 2.3K: Provides carboxyl-rich poly(amino acid) segments with multiple functional groups for molecular interactions and chemical modification.
- PEG MW 2K: Provides a hydrophilic central segment that contributes flexibility, hydration, and aqueous compatibility.
- Near-Balanced Architecture: The approximately 1.15:1 pAsp-to-PEG molecular weight ratio provides substantial carboxyl functionality together with a significant hydrophilic PEG component.
- Carboxyl-Rich Polymer: The pAsp blocks provide multiple pendant carboxyl groups specifically for conjugation, ionic interactions, and further chemical functionalization.
- Functionalizable Polymer Platform: Supports modification of pAsp carboxyl groups with amine-containing molecules through coupling strategies such as EDC/NHS chemistry.
- Poly(amino acid)-PEG Design: Combines functional poly(amino acid) segments with PEG for development of advanced polymeric and biomaterial systems.
Applications
- Polymer Functionalization: Provides multiple carboxyl groups for chemical modification and attachment of suitable functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, targeting ligands, and other molecules through carboxyl-group chemistry.
- Drug Delivery: Supports development of functional polymer-based drug delivery and carrier systems.
- Ionic Complex Formation: The carboxyl-rich pAsp segments can participate in electrostatic interactions with positively charged molecules and ions.
- Hydrogel Development: Supports development of crosslinked polymer networks and functional hydrogel systems through appropriate modification or crosslinking strategies.
- Surface Modification: Supports functionalization of nanoparticles, coatings, and other biomaterial surfaces.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials, conjugates, polymer networks, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines carboxyl-rich pAsp blocks with a hydrophilic PEG segment in a near-balanced triblock architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, hydrogel development, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
