Norbornene-PEG6 azide is a heterobifunctional polyethylene glycol (PEG) linker designed for advanced bioconjugation and material science applications. Specifically, it features a norbornene group that enables bio-orthogonal chemistry and an azide group compatible with copper-catalyzed or strain-promoted click reactions. Additionally, the PEG6 spacer enhances solubility, reduces steric hindrance, and improves biocompatibility. As a result, Norbornene-PEG6 azide serves as a highly versatile reagent in drug delivery, bioconjugation, and surface modification.
Key Features
- Heterobifunctional Design – Combines a norbornene group for bio-orthogonal reactions with an azide group for click chemistry, ensuring diverse applications.
- PEG6 Spacer – Enhances solubility, minimizes steric hindrance, and provides structural flexibility for efficient conjugation.
- High Biocompatibility – Reduces immunogenicity and enhances stability in biological environments.
- Versatile Reactivity – Facilitates site-specific conjugation in bioengineering, pharmaceuticals, and nanotechnology.
- Improved Hydrophilicity – Ensures better dispersion in aqueous systems, making it suitable for biomedical and polymer applications.
Applications
- Bioconjugation and Labeling – Enables efficient attachment of biomolecules such as proteins, peptides, and antibodies.
- Drug Delivery Systems – Enhances drug solubility and targeted delivery by modifying carrier molecules.
- Polymer and Material Science – Improves functionalization of surfaces and nanoparticles for biomedical and industrial use.
- Click Chemistry Reactions – Supports copper-catalyzed and strain-promoted azide-alkyne cycloadditions (CuAAC and SPAAC).
- Hydrogel and Biomaterial Development – Contributes to the creation of biocompatible hydrogels for tissue engineering and medical applications.
Conclusion
In summary, Norbornene-PEG6 azide is a highly functional and versatile PEG linker that bridges bio-orthogonal and click chemistry reactions. With its norbornene and azide groups, along with a flexible PEG6 spacer, it offers superior solubility, reactivity, and biocompatibility. Furthermore, its broad applications in drug delivery, bioconjugation, and material science make it an essential tool for researchers in pharmaceuticals, biotechnology, and polymer engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
