Norbornene-PEG2-Propargyl
This high-purity heterobifunctional PEG linker has a norbornene for rapid IEDDA cycloaddition with tetrazines and a terminal alkyne for CuAAC click chemistry. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance for especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Norbornene Group – Enables fast, bioorthogonal tetrazine ligation under mild, catalyst-free conditions.
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Propargyl Group – Supports CuAAC click chemistry for stable triazole formation with azide-containing molecules.
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PEG2 Spacer – Improves solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable, reproducible performance.
Applications
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Dual-functional linker for orthogonal conjugation strategies
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Protein, peptide, and nucleic acid labeling
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Multifunctional probe and diagnostic agent synthesis
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Antibody–drug conjugate (ADC) linker chemistry
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product combines tetrazine ligation via norbornene with CuAAC click chemistry through a terminal alkyne, linked by a PEG2 spacer for solubility and flexibility, specifically enabling precise orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
