N,N-Bis(PEG2-propargyl)-N-amido-PEG2-oxyamine
This high-purity PEG linker has two propargyl groups for CuAAC click chemistry and an aminooxy group for oxime ligation with aldehydes or ketones. PEG2 spacers specifically enhance solubility, flexibility, and reduce steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Dual Propargyl Groups – Support CuAAC click chemistry for stable triazole linkage formation with azide-containing molecules.
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Aminooxy Group – Reacts selectively with aldehydes and ketones to form stable oxime bonds under mild conditions.
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PEG2 Spacers – Improve solubility, flexibility, and accessibility of reactive sites.
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Orthogonal Reactivity – Enables sequential, site-specific conjugations without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible performance.
Applications
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Dual-mode orthogonal bioconjugation strategies
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Protein, peptide, and glycan labeling via oxime ligation and click chemistry
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Multifunctional probe and diagnostic agent synthesis
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Drug delivery system and ADC linker development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity
This product offers two propargyl groups for CuAAC and an aminooxy group for oxime ligation, with PEG2 spacers for solubility and flexibility, specifically enabling highly efficient, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
