Z-Lys-NCA is a side-chain-protected L-lysine N-carboxyanhydride monomer. Its Z (Cbz) group protects the ε-amino functionality during polymerization. Researchers use it in ring-opening polymerization specifically to synthesize protected poly(L-lysine) and related polypeptides.
Key Features and Benefits
- NCA Monomer: Nε-Z-L-Lysine N-Carboxyanhydride (Z-Lys-NCA) provides a reactive N-carboxyanhydride monomer for polypeptide synthesis.
- L-Lysine Derivative: The monomer derives from L-lysine and specifically provides an amino acid-based building block for polymer research.
- Nε-Z Protection: The Z (Cbz) group protects the side-chain ε-amino group while leaving the NCA functionality available for polymerization.
- Ring-Opening Polymerization: Supports NCA ring-opening polymerization for preparing synthetic lysine-based polypeptides.
- Poly(L-Lysine) Precursor: Serves as a protected monomer for synthesizing poly(L-lysine) and related polymer structures.
- Side-Chain Deprotection: Removal of the Z protecting groups exposes pendant amino groups specifically for further functionalization.
- Functional Polymer Platform: The protected amino functionality specifically supports controlled polymer synthesis followed by post-polymerization modification.
Applications
- Poly(L-Lysine) Synthesis: Researchers use Nε-Z-L-Lysine N-Carboxyanhydride (Z-Lys-NCA) to prepare protected poly(L-lysine) precursors.
- NCA Polymerization: Supports ring-opening polymerization using compatible initiators under suitable reaction conditions.
- Polypeptide Synthesis: Enables preparation of lysine-based homopolypeptides and copolypeptides.
- Block Copolypeptide Research: Supports copolymerization with compatible NCA monomers to prepare block and multicomponent polypeptides.
- Amine-Functional Polymer Research: Z deprotection exposes pendant ε-amino groups for subsequent chemical modification.
- Polymer Functionalization: Deprotected amino groups provide reactive sites for conjugation with compatible functional molecules.
- Biomaterial Research: Supports development of functional poly(amino acid)s and related polypeptide materials.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: NCA monomers are moisture sensitive. Handle under dry conditions and minimize exposure to atmospheric moisture before polymerization.
This product provides a protected NCA monomer for lysine-based polypeptide synthesis and specifically supports ring-opening polymerization, poly(L-lysine) preparation, block copolypeptide development, and polymer functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
