Positioned between high‑molecular‑weight 10K and ultra‑high‑molecular‑weight 20K variants, this 15 kDa azide‑terminated poly(ε‑caprolactone) achieves a unique balance of mechanical performance and degradation timeline. Further increased chain length brings intensified chain entanglement and higher crystallinity, while retaining bio‑orthogonal terminal azide groups for CuAAC‑mediated triazole formation with alkyne‑modified biomolecules. Slower hydrolytic kinetics support weeks‑to‑early‑multi‑month structural persistence, outperforming 10K in mechanical robustness without reaching the extreme erosion resistance of 20K grade. This polymer targets semi‑implant‑relevant experimental scenarios, where researchers require both click‑chemistry modular modification and prolonged material stability for intermediate implant‑mimic pre‑clinical assessment.
Key Features: ‑ Mid‑ultra‑high‑molecular‑weight PCL backbone with terminal azide functionality, delivering enhanced mechanical strength compared to 10K and lower‑molecular‑weight PCL‑N3 ‑ Weeks‑to‑early‑multi‑month degradation profile; maintains structural integrity under biological surroundings for extended pre‑experimental cycles before gradual bulk erosion ‑ Balanced solubility‑rigidity trade‑off; dissolves in common anhydrous organic solvents yet produces mechanically stable particles and thin electrospun membranes ‑ Outstanding bio‑orthogonal property; azide shows no spontaneous cross‑reactivity with native thiols, amines and hydroxyl groups, securing clean CuAAC click‑ligation outcomes ‑ Spectroscopically verified azide end‑group conversion rate; low residual impurities adapted for advanced cell research and semi‑implant‑related small‑animal model evaluation
Applications: ‑ Fabrication of highly stable azide‑labelled nanoparticles and micelles for long‑term drug release and prolonged in‑vivo biodistribution monitoring ‑ Click‑based surface bio‑functionalization of semi‑implantable electrospun membranes for medium‑to‑long‑term tissue integration investigation ‑ Synthesis of triazole‑linked polymer‑biomolecule conjugates for durable targeting systems oriented toward subcutaneous small‑animal studies ‑ Formulation development bridging long‑circulating nanocarriers and full implant‑grade ultra‑high‑MW PCL‑N3 materials ‑ Prototype evaluation of click‑modified polymer platforms for translational pre‑clinical pipelines before adopting 20K ultra‑slow‑degrading polymer grades
Handling & Storage: Store lyophilized polymer powder at −20 °C under dry inert‑gas environment. Even though azide moieties possess better anti‑hydrolysis capacity than maleimide, cumulative moisture exposure will still reduce click‑reaction efficiency over time. Place sealed vials inside desiccator and wait for full room‑temperature equilibration prior to opening, preventing condensed water from contaminating polymer solids. Prepare anhydrous‑solvent working solutions freshly before experiments; long‑term storage of dissolved polymer stock solutions is discouraged. This product is intended solely for laboratory research and is not eligible for human clinical usage.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.