N-NHS-PEG3-N-bisPEG3-azide
This product is a heterobifunctional PEG linker featuring an NHS ester on one end and two azide groups connected via PEG3 spacers. The NHS ester reacts efficiently with primary amines to form stable amide bonds, while the azides enable bioorthogonal click chemistry, making this reagent especially versatile for dual labeling and conjugation strategies.
Key Features and Benefits:
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NHS Ester Group: Provides rapid, efficient amine-reactivity under mild aqueous conditions.
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Dual Azide Groups: Enable multivalent CuAAC or SPAAC click chemistry with alkynes.
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PEG3 Spacers: Enhance solubility, flexibility, and reduce steric hindrance.
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High Purity: Ensures reliable results in protein, peptide, and biomolecule conjugation.
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Multifunctional Design: Supports orthogonal and stepwise conjugation workflows.
Applications:
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Bioconjugation: Site-specific thiol- and amine-reactive dual labeling of biomolecules.
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Click Chemistry: Multivalent azide handles for CuAAC or strain-promoted cycloadditions.
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Drug Delivery: Spacer-linker for attaching therapeutic payloads with precision.
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Surface Modification: Functionalize nanoparticles, hydrogels, or polymers with amine and click-reactive groups.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use freshly prepared anhydrous solutions (e.g., DMF, DMSO) for maximum stability.
This product combines amine-reactivity with multivalent azide click chemistry, offering an especially powerful linker for advanced bioconjugation and dual-labeling applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
