N-Mal-N-bis(PEG2-NH-Boc)
This product is a multifunctional PEG linker containing a maleimide group and two Boc-protected PEG2 amines. It specifically enables thiol conjugation and orthogonal amine chemistry after deprotection, offering solubility, compact design, and versatile reactivity.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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Boc-Protected Amines: Allow orthogonal reactivity after controlled deprotection.
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PEG2 Spacers: Enhance solubility while maintaining compact flexibility.
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Multifunctional Design: Combines thiol reactivity with protected amine handles.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with PEG scaffolds and amines.
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Probe Development: Builds multifunctional probes with thiol and amine handles.
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Drug Delivery: Provides PEG scaffolds for dual reactive and protected conjugation.
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Organic Synthesis: Serves as an intermediate in modular linker chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Boc loss.
This product integrates thiol-reactive maleimide chemistry with Boc-protected amines in PEG2 scaffolds, specifically offering solubility and staged conjugation versatility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
