N-Fmoc-N’-(azido-PEG4)-L-Lysine- PFP ester

N-Fmoc-N’-(azido-PEG4)-L-Lysine-PFP ester

This product is a protected lysine derivative featuring an Fmoc-protected α-amine, an azide-modified PEG4 side chain, and a tetrafluorophenyl (PFP) ester for efficient coupling. This multifunctional design specifically enables orthogonal synthesis, click chemistry, and controlled bioconjugation in peptide and probe development.

Key Features and Benefits:

• Fmoc Protection: Provides orthogonal control for stepwise peptide synthesis.

• Azide-PEG4 Side Chain: Enables CuAAC or SPAAC click chemistry with alkynes.

• PFP Ester: Couples rapidly with amines to form stable amide bonds.

• PEG4 Spacer: Enhances solubility and steric accessibility.

• High Purity: Ensures reproducibility in sensitive workflows.

Applications:

• Peptide Synthesis: Incorporates azide functionality into peptide backbones.

• Probe Development: Builds multifunctional peptides and conjugates for imaging.

• Drug Discovery: Supports design of clickable, PEGylated therapeutic candidates.

• Bioconjugation: Combines amine reactivity, orthogonal protection, and click handles.

Storage and Handling:

• Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature hydrolysis of the PFP ester.

This product integrates Fmoc-protected peptide chemistry, a PEG4-linked azide handle, and amine-reactive ester, specifically offering versatility for orthogonal synthesis and click-ready conjugation.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.