N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester CAS:2112731-94-7 is a high-purity, bifunctional polyethylene glycol (PEG) linker extensively employed in pharmaceutical research and development. This molecule features two distinctive functional groups: an azide moiety at one terminus and a tert-butyl ester-protected carboxylic acid group at the other.
The azide group enables click chemistry applications, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating the rapid and selective formation of covalent connections between molecular entities. This feature has made it an invaluable tool in drug conjugation, bioconjugation, and polymer synthesis.
The N-Boc-protected amine and t-butyl ester groups provide orthogonally protected sites for further functionalization or coupling reactions, while allowing for straightforward deprotection under mild conditions. This characteristic ensures compatibility with sensitive bioactive molecules and complex reaction schemes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
