N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester
This product is a multifunctional PEG linker containing an azide group, a Boc-protected amine, and a t-butyl ester. It specifically enables bioorthogonal click chemistry, orthogonal amine deprotection, and carboxyl functionality after ester cleavage.
Key Features and Benefits
-
Azide Group: Reacts with alkynes via CuAAC or SPAAC click chemistry.
-
Boc-Protected Amine: Allows orthogonal reactivity after selective deprotection.
-
t-Butyl Ester: Provides a protected carboxyl group for controlled release.
-
PEG3 and PEG4 Spacers: Improve solubility and reduce steric hindrance.
-
High Purity: Ensures reproducibility in multifunctional bioconjugation workflows.
Applications
-
Bioconjugation: Links azide- and amine-containing biomolecules with orthogonal control.
-
Probe Development: Builds multifunctional probes with protected and active handles.
-
Drug Delivery: Provides PEG scaffolds with controlled activation points.
-
Organic Synthesis: Serves as a versatile precursor for multifunctional linkers.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates azide click chemistry, protected amine reactivity, and ester-protected acid functionality, specifically offering a powerful scaffold for modular linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
